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Details of Grant 

EPSRC Reference: GR/R45659/01
Title: BIO-NANOTECHNOLOGY IRC
Principal Investigator: Ryan, Professor J
Other Investigators:
Watts, Professor A Armitage, Professor J Sansom, Professor M
Molloy, Dr J Cooper, Professor J Trentham, Dr D
Pethica, Professor J Turberfield, Professor AJ
Researcher Co-Investigators:
Professor A Asenov Professor Dame FM Ashcroft Professor RM Berry
Professor R Codgell Dr J Corrie Professor DRS Cumming
Professor PJ Dobson Dr D Doyle Dr J Eccleston
Dr M Ferenczi Professor MLH Green Professor H Hill
Dr J Hoggett Professor N Isaacs Professor L Johnson
Professor N Johnson Professor AG Lee Professor H Morgan
Professor RJ Nicholas Professor D Sherratt Professor G Smith
Professor RE Sockett Professor E Southern Professor JC Sparrow
Dr RK Thomas Dr C Veigel Professor JMR Weaver
Professor C Wilkinson Professor J Yeomans
Project Partners:
Department: Oxford Physics
Organisation: University of Oxford
Scheme: Standard Research (Pre-FEC)
Starts: 01 April 2002 Ends: 31 March 2009 Value (£): 9,829,772
EPSRC Research Topic Classifications:
Biological & Medicinal Chem. Biomaterials
Cells Chemical Biology
Microsystems
EPSRC Industrial Sector Classifications:
Pharmaceuticals and Biotechnology Electronics
Healthcare
Related Grants:
Panel History:  
Summary on Grant Application Form
The IRC aims to investigate biomolecular systems, from the level of single molecules up to complex molecular machines, to establish the principles of their function and apply this knowledge to produce artificial electronic and optical devices:Molecular motors are proteins in which enzymatic activity such as energy conversion and self-assembly are integrated to produce highly efficient linear or rotary motion on a nanometre length scale. The combination of structural biology, molecular genetics and biophysics will allow the mechanisms to be characterised and potential applications to be identified.Membrane proteins can be viewed as one of evolution's main attempts at nano-engineering: they include ion channels, hormone receptors and photoreceptors. High resolution (spatial and temporal) studies of ion channels and related membrane proteins will be made via novel time-resolvedoptical spectroscopy and single molecule techniques.'Molecular genetic analysis needs efficient ways of comparing sequences: to search for mutations it is necessary to scan entire gene sequences. Combined nano-fabrication and genetics methods will be used to produce patterned surfaces, and more sensitive methods of detecting interactions will be developed in order to push toward the single molecule limit.Single-molecule electronics and photonics will be used to develop novel devices, networks and sensors.Single molecule and scanning probe experimental techniques including AFM, STM, optical and dielectric traps, FTIR, and SNOM will underpin the entire IRC programme. Theoretical approaches with common themes will be developed and applied - including Monte Carlo methods, atomic force models, and techniques derived from semiconductor device simulations.
Key Findings
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Summary
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Further Information:  
Organisation Website: http://www.ox.ac.uk