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Details of Grant 

EPSRC Reference: GR/R41019/01
Title: Building a patient-specific model of the heart for integrated diagnosis and treatment of tachyarrhythmias by RF-ablation.
Principal Investigator: Hill, Professor DL
Other Investigators:
Hawkes, Professor D Razavi, Professor R Baker, Dr E
Hill, Dr D Hawkes, Dr D Rosenthal, Dr E
Researcher Co-Investigators:
Project Partners:
Kings College London
Department: BHS School Management
Organisation: Kings College London
Scheme: Standard Research (Pre-FEC)
Starts: 01 February 2002 Ends: 31 January 2005 Value (£): 279,016
EPSRC Research Topic Classifications:
Image & Vision Computing
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
Panel History:  
Summary on Grant Application Form
Disturbances of the rhythm of the heart (tachyarrhythmias) are potentially life-threating illnesses which can affect people of ail age groups. 1n patient who are unresponsive to drug treatment, radio-frequency (RF) ablation of electrophysiologocal conduction pathways and foci is the only available treatment. Currently the localisation and diagnosis of tachyarrhythmias is a highly invasive and complicated procedure which requires the insertion of catheter into the heart under X-ray guidance. We propose a novel method for the non-invasive diagnosis of tachyarrhythmias and their treatment.The key element of the proposed research aims to detect and localise electrophysological conduction pathways and foci through correlation with patterns of myocardial motion and contraction which will be extracted from tagged MR imaging. We will develop novel MR imaging sequences based retrospective gating which will be optimised towards imaging premature myocardial contraction. Based on these MR images we will build a patient specific model of cardiac anatomy and function showing conduction foci as well as pathways which indicate the propagation of electrical depolarisati< We anticipate developing a system which allows clinicians to pre-operatively plan the RF ablation procedure and to transfer this plan to the intraoperative scene. Finally, we aim to apply and evaluate the developed methods in 30 patients undergoing treatment of tachyarrhythmias.
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