| EPSRC Reference: |
GR/R07493/01 |
| Title: |
Novel Nanoscale Latent Photoelectronic Detectors Formed By Biological, Target-Directed, In Situ Assembly |
| Principal Investigator: |
Douglas, Professor K |
| Other Investigators: |
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| Department: |
Pharmacy, School of |
| Organisation: |
Victoria University of Manchester, The |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 September 2000 |
Ends: |
31 August 2001 |
Value (£): |
51,529
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| EPSRC Research Topic Classifications: |
| Analytical Science |
Biological & Medicinal Chem. |
| Chemical Biology |
Co-ordination Chemistry |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
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Summary on Grant Application Form |
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We propose a new general system for very specific signal transduction at nucleic acid target sequences, and with virtually no background signal. DNA systems will be used for proof of concept, in bulk solution (fluoro detection) and at chemically derivatised surfaces (electro detection). The high fidelity recognition properties of complementary DNA strands for each other will be used in combination with detailed 3-dimensional knowledge of the target site chosen. There will be little or zero background because of the way in which the detector structures are designed. Many possible detection systems can be used in principle, but for rapid translation to a test system we shall use luminescence in Phase 1, and electrochemical transduction at a surface in the next phase. The project uses the techniques of rational molecular design from medicinal and biological chemistry and applies them to the interface of co-ordination chemistry and nucleic acid science to provide the basis of new approaches to optoelectronic devices and smart materials with application in nanotechnology, in particular in detectors based on fluorescent and/or photosensitizing dyes.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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