| EPSRC Reference: |
GR/A11304/01 |
| Title: |
AF: NEXT GENERATION BIOMEDICAL MATERIALS FROM SUPERCRITICAL FLUIDS |
| Principal Investigator: |
Darr, Professor J |
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| Department: |
Biomedical Materials |
| Organisation: |
Queen Mary University of London |
| Scheme: |
Advanced Fellowship (Pre-FEC) |
| Starts: |
01 October 2001 |
Ends: |
30 September 2006 |
Value (£): |
227,422
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| Healthcare |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The proposed research aims to manufacture better artificial bone materials from extremely small nano-sized building blocks in order to improve bulk mechanical and/or biological properties. The nanoparticles will be prepared in surfactants that can assemble to form 'reverse micelle' aggregates in high-pressure supercritical fluids (with or without water inside their cores). Initially, the phase behaviour and micelle forming abilities of surfactants will be assessed using a variety of methods. Selected surfactant/supercritical fluid mixtures will then be used to manufacture nanoparticulate novel calcium phosphates (CAPS), titania and tetragonal phase stabilised zirconia. Chosen reactions will be scaled-up to gain enough material for the preparation of mechanical and biological (in vivo/in vitro) test specimens. These specimens will be either sintered disks (CAPs and zirconia), porous blocks (CAPs) or polymer/ceramic composites (CAP). The phase purity and chemical composition of the nanoparticles and test specimens will be characterised using techniques such as FT-IR, FT-Raman and UV/Vis. spectroscopy, Powder X-ray Diffraction (PXD), X-ray Fluorescence (XRF), Inductively Coupled Plasma-Mass Spectrometry (ICP-MS), Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA).
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Key Findings |
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Potential use in non-academic contexts |
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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