Details of Grant 

EPSRC Reference:	GR/T19797/01
Title:	Application of High Resolution Nanosims Analysis in the Biological Sciences
Principal Investigator:	Grovenor, Professor C
Other Investigators:	Dilworth, Professor J Harris, Professor D Rickaby, Professor R Belshaw, Dr N
Researcher Co-Investigators:
Project Partners:	GE Healthcare Procter & Gamble
Department:	Materials
Organisation:	University of Oxford
Scheme:	Standard Research (Pre-FEC)
Starts:	01 October 2005	Ends:	31 March 2009	Value (£):	268,276
EPSRC Research Topic Classifications:	Drug Formulation & Delivery Med.Instrument.Device& Equip.
EPSRC Industrial Sector Classifications:	Environment Healthcare
Related Grants:
Panel History:	Panel Date Panel Name Outcome 16 Sep 2004 Healthcare Prioritisation Panel (Engineering) Deferred
Summary on Grant Application Form
The applicants have identified 3 projects in the Life Sciences where well established research programmes are running in Oxford and within which a critical need for improved high resolution, high sensitivity chemical analysis has been demonstrated. Our primary aim in each project area is to obtain subcellular chemical information on the distribution of dilute metallic species critical for the understanding of a key process or to validate a drug targeting study. In each case this data has proved difficult (or impossible ) to achieve by other, more conventional, techniques. These projects are:Subcellular analysis of the location and reaction pathways for radiopharmaceuticals The intercellular role of Mg ions in energy generation in human and plant subjects Transport pathways of biomineralisation in marine organismsWe propose to investigate these 3 projects with the CAMECA NanoSIMS50 recently installed in the Oxford Materials Department, funded by an EPSRC JIF grant. This instrument offers a combination of lateral resolution and sensitivity unique in the UK, and ideally suited to the challenging experiments on sub-cellular mapping of dilute ions.
Key Findings
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Potential use in non-academic contexts
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Further Information:
Organisation Website:	http://www.ox.ac.uk