| EPSRC Reference: |
GR/S13668/01 |
| Title: |
In Situ Fabricated Membranes for Selectivity and Biocompatibility in Microanalytical Systems |
| Principal Investigator: |
Vadgama, Professor P |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Biomedical Materials |
| Organisation: |
Queen Mary University of London |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 August 2003 |
Ends: |
31 August 2006 |
Value (£): |
363,400
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| EPSRC Research Topic Classifications: |
| Analytical Science |
Chemical Biology |
| Electrochemical Science & Eng. |
Fluid Dynamics |
| Materials Characterisation |
Materials Processing |
| Separation Processes |
Surfaces & Interfaces |
| Tissue Engineering |
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| EPSRC Industrial Sector Classifications: |
| Healthcare |
No relevance to Underpinning Sectors |
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| Panel History: |
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Summary on Grant Application Form |
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A series of ultra-thin liquid interface membranes will be produced using parallel laminar flows in low Reynolds number cells with the capability of providing rapid, selective transport, but with a series of novel characteristics not seen with existing casting techniques. Fine-tuning of the fabrication procedure will favour dominance of surface over bulk properties, enhance permselectivity control and decrease fouling through control of surface topography and surface polymer flexibility. Through suspension of membranes above an electrochemical sensing surface, internal reagent and electrolyte renewal as well as changes to solute transport should be achieved. Under fully characterised parallel flow conditions, computational models for polymer transport to the liquid-liquid interface membrane and later membrane desolvation will provide important insights into the membrane forming process.Membrane-based electrochemical biosensors protected from colloidal samples but with a membrane bound internal film layer allowing bioreagent resupply for stable operation will be investigated for operational stability. Cell seeded membrane reactors for both biosensing and tissue engineering applications will be examined utilising the membrane as a supporting layer for the cells and the subjacent flows as means of delivery of nutrients to the across the membrane layer.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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