| EPSRC Reference: |
GR/R80230/01 |
| Title: |
CHARACTERISATION OF FLUCTUATIONS IN CEREBRAL HAEMODYNAMICS AND OXYGENATION |
| Principal Investigator: |
Elwell, Professor CE |
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| Department: |
Medical Physics and Biomedical Eng |
| Organisation: |
UCL |
| Scheme: |
Fast Stream |
| Starts: |
01 October 2002 |
Ends: |
31 March 2004 |
Value (£): |
61,922
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| EPSRC Research Topic Classifications: |
| Biomedical neuroscience |
Digital Signal Processing |
| Med.Instrument.Device& Equip. |
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Summary on Grant Application Form |
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The purpose of this research is to experimentally record and mathematically model the fluctuations in cerebral haemodynamics and oxygenation. To date, thorough investigations of the rapid systemically related (e.g. cardiac and respiratory) and spontaneous variations in the human cerebrovascular system have been limited by the temporal resolution of most conventional measurement techniques. Near infrared spectroscopy (NIRS) exploits the relative transparency of biological tissue to light between 700 -1000nm to provide spectroscopic measurements of the concentration of oxy and deoxyhaemoglobin. Developments in optical data acquisition systems have increased temporal resolution to at least 20Hz, allowing rapid changes in the cerebral haemodynamics to be detected in the normal brain for the first time. In addition, absolute values for cerebral oxygenation (including the tissue oxygenation index) can now be measured on two sites simultaneously, allowing phase relationships between localised changes in different areas of the brain to be Investigated. This project will involve data acquisition from normal subjects in whom cerebral and systemic parameters will be recorded at rest and during functional activation. Characterisation of signals will take the form of a mathematical model in which will be designed to determine the true haemodynamic status of the resting brain. Submitted as a Fast Stream application, this project will enable the principal investigator, in her new academic post, to continue her career aim of establishing an independent research record within the field of cerebrovascular studies,
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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