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Details of Grant 

EPSRC Reference: GR/R47646/01
Title: Upgrade of 500 and 250 MHz NMR spectrometers for Pharmaceutical Chemistry Research.
Principal Investigator: Patterson, Professor L
Other Investigators:
Searcey, Professor M Gibbons, Professor S Williamson, Professor EM
Welham, Dr K Smart, Dr T Heinrich, Professor M
Zloh, Professor M WILDERSPIN, Dr AF Florence, Dr AT
Falconer, Dr R Florence, Professor A Gregoriadis, Professor G
Brocchini, Professor SJ
Researcher Co-Investigators:
Project Partners:
Department: School of Pharmacy
Organisation: UCL
Scheme: Standard Research (Pre-FEC)
Starts: 20 December 2001 Ends: 19 December 2006 Value (£): 403,457
EPSRC Research Topic Classifications:
Biological & Medicinal Chem. Drug Formulation & Delivery
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors Pharmaceuticals and Biotechnology
Related Grants:
Panel History:  
Summary on Grant Application Form
We are seeking to upgrade the University of London School of Pharmacy's NMR service, which at present comprises AM500MHz and AM250M spectrometers. It is proposed to replace the exisiting consoles with the new Bruker AVANCE instrumentation with additional software, data-handling capability and probes.The upgrade of the 500MHz machine will include the provision of a third digital channel which will give access to C-H-X experiments necessary for the structure elucidation of macromolecules. Both instruments will have the ability to perform gradient-assisted spectroscopy which will enhance the School's ability to acquire high resolution data rapidly and aid in the acquisition of spectra on small amounts of biologically active materials.It is proposed to retain the existing magnets and the School has in place an annual budget for their running and maintainance costs. We therefore believe that an upgrade is the most cost effective and competitive solution for the service. A maintenance contract is included in the proposal and will also support the continued effective running of the service.The upgrade is essential if we are to maintain our RAE 5 rating in research excellence in the Pharmaceutical Sciences.
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