| EPSRC Reference: |
GR/R40845/01 |
| Title: |
Rubber Toughened Methacrylate Systems as Delivery Prostheses of Dual Antimicrobial Agents in the Treatment of Oral Biofilms |
| Principal Investigator: |
Nazhat, Dr SN |
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| Department: |
Biomaterials Science |
| Organisation: |
Eastman Dental Institute for Oral Health |
| Scheme: |
Fast Stream |
| Starts: |
01 August 2001 |
Ends: |
30 September 2003 |
Value (£): |
53,808
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| EPSRC Research Topic Classifications: |
| Biomechanics & Rehabilitation |
Drug Formulation & Delivery |
| Materials Characterisation |
Materials Synthesis & Growth |
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Summary on Grant Application Form |
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This proposal aims to develop prosthetic devices based on rubber toughened methacrylates for the delivery of antimicrobial agents in the treatment o biofilms in the oral cavity. This can be carried out by releasing combinations of therapeutic agents in a controlled manner subgingivally at the site of infection, aiming at both the polysaccharide matrix and the bacterial cells that make up the biofilms. The necessary conditions for developing pharmaceutically applicable polymers will depend upon having a detailed knowledge of the relationship between the structure and properties of polym networks. The efficacy of this drug delivery system will be assessed using a combination of antimicrobial agents. The research will focus on the relationship between the viscoelastic properties of the materials and release kinetics of the drugs. Dynamic mechanical analysis (DMA) will be the primary technique for characterising the thermomechanical properties to analyse the interaction between the polymer components and their interactio with a number of therapeutic agents. DMA will also be used to carry out real time studies to assess the effect of cyclic loading on the rate of release ~ these antimicrobials. Biological analyses will assess the efficacy of these antimicrobials and determine the optimum release mechanisms in the treatment of biofilms in vitro using the constant depth film fermentor.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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