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Details of Grant 

EPSRC Reference: GR/R08834/01
Title: From Micrograms To Multikilos
Principal Investigator: Gavriilidis, Professor A
Other Investigators:
Blackmond, Professor DG Roberts, Professor S
Researcher Co-Investigators:
Project Partners:
Anachem Ltd AstraZeneca Avecia Limited
Chirotech Technology Limited Clariant Life Science Molecules Synthesi GlaxoSmithKline plc (GSK)
Laboratory of Government Chemist Organic Intermediates Pfizer
Scientific Update Stylacats Ltd Ultrafine (Ufa) Ltd
Department: Biochemical Engineering
Organisation: UCL
Scheme: FORESIGHT LINK
Starts: 30 April 2001 Ends: 29 January 2005 Value (£): 415,892
EPSRC Research Topic Classifications:
Reactor Engineering
EPSRC Industrial Sector Classifications:
Chemicals Pharmaceuticals and Biotechnology
Related Grants:
GR/N16525/01 GR/R08896/01
Panel History:  
Summary on Grant Application Form
Combinatorial chemistry has resulted in the more rapid discovery of lead-compounds in the pharmaceutical and agrochemical areas. As a consequence, bottle-necks occur when the lead-compounds need to be produced on a large scale, for which the techniques of combichem are inappropriate. The process of route-definition and scale-up extends the time-to-market. It is widely agreed that in the vast majority of cases the speedy implementation of a suitable manufacturing process will only be achieved by a focused team comprising synthetic organic chemists, physical organic chemists, analytical chemists and chemical engineers. The key is to begin with the commonalities: the link between chemists and chemical engineers is the chemical reaction itself. While it may not be the speciality of either, chemical kinetics and the physical properties of reacting systems are familiar to both groups. This proposal therefore begins with kinetics and brings the fruits of fundamental kinetic studies upstream into organic synthetic strategy, as well as downstream into reactor design. The chemical reaction is the link which may be used to help all parties in the process research and development spectrum to begin to speak a common language.
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