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Details of Grant 

EPSRC Reference: GR/R06816/01
Title: High Resolution Optical Tomographic Imaging of In Vivo Micro-Circulation
Principal Investigator: Wang, Professor R
Other Investigators:
Wright, Dr G El Haj, Professor A Elder, Professor J
Morgan, Dr R
Researcher Co-Investigators:
Project Partners:
Department: Sch of Medicine
Organisation: Keele University
Scheme: Standard Research (Pre-FEC)
Starts: 15 June 2001 Ends: 28 February 2002 Value (£): 238,151
EPSRC Research Topic Classifications:
Med.Instrument.Device& Equip. Medical Imaging
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
Panel History:  
Summary on Grant Application Form
Doppler Optical coherence tomography (DOCT) is a recent advent and powerful technique that can provide microscopic tomographic imaging of microcirculations simultaneous with microstructure features of biological tissue. This proposal aims to develop a real world DOCT system capable of characterising amnd monitoring blood flow functionally with high spatial resolution (2-10 microns) at user-specified locations in highly scattering biological tissues, to aid diagnosis and assessment of tissue abnormalities, surgical and phamacological interventions. We will first resolve the physics and engineering problems underlying DOCT in order to clarify what is the maximum imaging depth and how instrumentation parameters and optical properties of both the flowing and static medium might influence the system performances. The technique will then be applied to record the DOCT images through highly scattering media and animal models in vivo. We intend to establish the ultimate limits of this technology and to define precisely the required specifications of an optimal system that is suitable for clinical use. It is believed that the instrument which which permits high resolution functional imaging of microcirculation will impact significantly on monitoring perfusion and viability before, during and after reconstructive procedures, determining the efficicacy of pharmacological intervention for failing surgical skin flaps or replants,etc.
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Summary
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Further Information:  
Organisation Website: http://www.keele.ac.uk