| EPSRC Reference: |
GR/R05154/01 |
| Title: |
IMI: Activated Carbon Haemoadsorbents For the Removal of Middle Molecular Weight and Other Toxins From Blood |
| Principal Investigator: |
Mikhalovsky, Professor S |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Sch of Pharmacy & Biomolecular Sciences |
| Organisation: |
University of Brighton |
| Scheme: |
LINK |
| Starts: |
01 January 2001 |
Ends: |
30 June 2004 |
Value (£): |
240,357
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| EPSRC Research Topic Classifications: |
| Medical science & disease |
Separation Processes |
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Summary on Grant Application Form |
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This project is focused on synthesis, characterisation and biomedical evaluation of uncoated medical grade activated carbons in the treatment of patients with acute and chronic renal failure. These novel carbons will be used for direct contact with blood and other bodily fluids due their high biocompatibility. It will be achieved by using porous synthetic polymers-precursors with full control over their chemical composition and porous structure followed by control of the carbon surface chemistry to prevent changes in the electrolyte composition of blood brought in contact with the adsorbent.A unique mesoporous structure of carbon adsorbents will be tailor-made to allow fast and efficient adsorption of 'middle-molecules' - substances playing important role in the pathology of renal failure that are not removed efficiently by other methods.Adsorption capacity and kinetics of activated carbons towards uraemic toxins and drugs causing renal failure will be evaluated in vitro and ex vivo from blood, ultrafiltrate and dialysate of acute and chronic renal patients. Target substances include: area, uric acid, creatinine, phosphate, potassium, carbamazepine, ibuprophen, inflammatory cytokines and (2-microglobulin.An extensive evaluation of haemo/biocompatibility of carbons, metods of their sterilisation and storage will be carried out.Efficiency of adsorption devices in-line with other extracorporeal methods will be assessed and a preliminary cost-benefit analysis will be done.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bton.ac.uk |