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Details of Grant 

EPSRC Reference: GR/N30743/01
Title: (ROPA) THE ATOM EFFICIENT GENERATION,STRUCTURE & REACT IVITY OF UNKNOWN METAL ENOLATES FOR ORGANIC SYNTHESIS
Principal Investigator: Motherwell, Professor WB
Other Investigators:
Researcher Co-Investigators:
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Department: Chemistry
Organisation: UCL
Scheme: ROPA
Starts: 06 September 2000 Ends: 05 February 2003 Value (£): 104,564
EPSRC Research Topic Classifications:
Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:
Chemicals Pharmaceuticals and Biotechnology
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Summary on Grant Application Form
A range of hitherto unknown metal enolates will be prepared in pure form using transition metal catalysts to mediate isomerisation of allylic metal akoxide precursors. The structure and reactivity of the products will be examined with particular attention given to reactions such as the regio-and stereospecific generation of tetrasubstituted enolates which are problematic using the atom inefficient deprotonation of carbonyl compounds by amide bases. The use of chiral ligands around the metals, in conjunction with prochiral allylic alcohols should provide useful chiral units for synthesis.
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