| EPSRC Reference: |
GR/M93888/01 |
| Title: |
APPROACHES TO THE TOTAL SYNTHESIS OF BRYOSTATINS |
| Principal Investigator: |
Thomas, Professor EJ |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
Victoria University of Manchester, The |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 January 2001 |
Ends: |
31 December 2003 |
Value (£): |
170,218
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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| Panel History: |
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Summary on Grant Application Form |
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It is proposed to continue with a research programme concerned with completing a total synthesis of bryostatins. A new approach recently developed for the synthesis of cis-2,6-6-disubstituted tetrahydropyrans is to be applied to complete a synthesis of the C(5) -C(16) fragment of the bryostatins and the product obtained will be elaborated to complete a synthesis of the C(1) - C(16) fragments. This will then be coupled to the C(17) - C(27) fragment using a Julia reaction and the product taken through to complete a synthesis of bryostatin 11. Preliminary studies of a synthesis of bryostatin 3 will also be undertaken.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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