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EPSRC Reference: GR/M32054/01
Title: JREI:DEEP DIFFUSIVE IMAGING IN TURBID MATERIALS AND SOFT SOLIDS BY PHOTON CORRELATION
Principal Investigator: Clarke, Professor DJ
Other Investigators:
Ferguson, Professor MWJ Berk, Dr DA Attwood, Professor D
Watts, Professor DC Stratford, Professor I
Researcher Co-Investigators:
Project Partners:
DSTL Air Systems Bedford Victoria University of Manchester, The
Department: Pharmacy, School of
Organisation: Victoria University of Manchester, The
Scheme: JREI
Starts: 01 June 1999 Ends: 31 May 2002 Value (£): 55,426
EPSRC Research Topic Classifications:
Instrumentation Eng. & Dev.
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors Manufacturing
Related Grants:
Panel History:  
Summary on Grant Application Form
The quantum jump of economic optical imaging (>10 fold deeper and 3D data from a single plane retroreflected scan) is enabled by a new high speed photon correlator, which circumvents the fundamental (timing) limit and expense of recent optical time of flight methods. Present (low resolution) imaging uses either high frequency ionising (eg X ray) transmission or low frequency (eg ultrasound, MR imaging) techniques. We will investigate intact soft materials, such as polymer gels and tissue without disruption into dilute suspensions or preparation of thin sections, particularly the unique resolution of their dynamic interactions (microviscosity, flow) as well as static refractive parameters. Biomedical fluorescent probes cannot be presently resolved above high sample (eg-autofluorescence) background. Correlation of individual fluorescent photons will be investigated to recover signal from such sparse probes: uniquely monitoring the diffusion of individual fluorescent centres and their unique fluorescent decay signatures. Initial industrial (eg undersea, fog, smoke), polymer materials (eg pharmaceutical, dental) and medical (eg cancer, wound healing) applications will be investigated within existing major programmes (over lOM), and a basis for wider academic and industrial collaboration established of potential major human and environmental benefit. Start date: 1 May 1998. Period: 36 months
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