| EPSRC Reference: |
GR/L63167/01 |
| Title: |
THE DIRECTED DIHYDROXYLATION OF FUNCTIONALISED ALKENES |
| Principal Investigator: |
Donohoe, Professor T |
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| Department: |
Chemistry |
| Organisation: |
Victoria University of Manchester, The |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
27 October 1997 |
Ends: |
26 October 2000 |
Value (£): |
148,927
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| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The programme is designed to investigate and exploit a novel oxidation system that we have discovered recently. The combination of osmium tetraoxide and TMEDA has been shown to allow the directed dihydroxylation of functionalised alkenes, using hydrogen-bonding as a control element. This is an interesting new reaction, and we aim to explore its scope and prepare sterochemically defined triols and tetraols in a manner that was previously unknown. Both cyclic and acylic systems will be investigated, together with homoallylic alcohols and sulfonamides.We then aim to use this new chemistry to enable the synthesis of biologically important compounds in a novel and particularly concise manner: targets are mannostatin and the cyclopentane moiety of funiculosin.In addition, the application of some inorganic chemistry should enable us to understand and improve upon this new oxidising reagent, with the ultimate aim of developing a catalytic process for the syn selective dihydroxylation of functionalised alkenes. We would also like to use this methodology to develop a simple test for the ligand acceleration effect.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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