| EPSRC Reference: |
GR/K99428/01 |
| Title: |
IN SITU MONITOR FOR STUDY & DEVELOPMENT OF CONTROL OF DELIVERY SYSTEM MANUFACTURE |
| Principal Investigator: |
Clarke, Professor DJ |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Pharmacy, School of |
| Organisation: |
Victoria University of Manchester, The |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 January 1996 |
Ends: |
30 September 1996 |
Value (£): |
46,749
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| EPSRC Research Topic Classifications: |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Food and Drink |
| Pharmaceuticals and Biotechnology |
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Summary on Grant Application Form |
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Micro- and nano-particles (polymers, micelles, microemulisions, vesicles, liposomes) are increasingly used as support matrices in industry (pharmaceutical, coatings, food, agriculture, personal hygiene). The support of active ingredients (drugs, paints, funtional foods, pesticides/herbicides/fertilisers, cosmetics and detergents/soaps). The support matrix increasingly serves a number of funtions (environmental protection, slow, controlled and/or responsive release, targeted delivery etc). These functions matrices share much in common across industry. They are usually produced at high concentraiton (eg dense or viscouse suspentions), which are difficult to monitor routinely without priour dillution, dramatically affecting their properties and production. Simple to apply and automated physical monitoring methods are needed, which operate in situ without affecting the processes to enable UK research and industry to develop innovative manufacturing processes, to optimise manufacture and improve quality control. Dielectric dipole relaxation measurements report on the macrostructure and molecular properties of such matrices. Advances in dynamic light scattering, normally unable to report on dense suspensions provide size and viscosity information. As both can be applied simply in situ and report on near real time we propose their combination and study in existing research and future studies with industry and other bodies with interest in such materials and processing advances.
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Key Findings |
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Potential use in non-academic contexts |
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Impacts |
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| Description |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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