| EPSRC Reference: |
GR/A90077/01 |
| Title: |
R/F.DEVELOPMENT & EVALUATION NOVEL MACRO-POROUS SYNTHETIC BONE-GRAFT FOR THE REPAIR OF OSSEOUS DEFECTS |
| Principal Investigator: |
Hing, Dr K |
| Other Investigators: |
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| Department: |
Biomedical Materials |
| Organisation: |
Queen Mary University of London |
| Scheme: |
Advanced Fellowship (Pre-FEC) |
| Starts: |
01 October 1999 |
Ends: |
31 December 2005 |
Value (£): |
217,733
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| EPSRC Research Topic Classifications: |
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| EPSRC Industrial Sector Classifications: |
| Healthcare |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The combination of; an aging population, advances in surgical technique and expectations of an improved quality of life, have led to an increased demand for bone grafts to repair and restore the function of old and diseased bone. To date, human bone, harvested from the patient or a donor, has been successfully employed, however, the demand for this material now far outstrips the supply. Current technology for the production of synthetic bone graft materials is expensive and non-optimised, it is based around the chemical conversion of natural porous structures such as coral into a biocompatible ceramic, hydroxyapatite. However, the flexibility of the process is limited by the chemistry and structure of the precursor. Furthermore, factors that control and promote bone repair within a synthetic macro-porous bone graft (termed osseointegration) are poorly understood and this has resulted in the supply of non-optimised material.The objective of this research project is to explore the mechanisms underpinning osseointegration, in order to evaluate the effect of the inter-play between mechanical, structural and chemical properties on the local osseous tissue. Osseointegration will be investigated by the application of a novel processing route, developed at the IRC, to produce a series of porous bioceramics where first the macro-structure and then the chemistry will be systematically varied in order to alter the mechanical, structural and chemical properties of the materials. All materials will be thoroughly characterised in terms of chemistry, macro-structure and mechanical properties, before the biological response to variations in structure and chemistry are evaluated both in vitro and in vivo. This information will then be applied to the design of optimised synthetic bone grafts for clinical application, where rapid restoration of bone function is required.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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