| EPSRC Reference: |
GR/R94770/01 |
| Title: |
ROPA: Calorimetric study into intestinal lipid digestion and drug absorption |
| Principal Investigator: |
Forbes, Professor B |
| Other Investigators: |
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| Department: |
Pharmacy |
| Organisation: |
Kings College London |
| Scheme: |
ROPA |
| Starts: |
24 February 2003 |
Ends: |
23 February 2004 |
Value (£): |
55,563
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| EPSRC Research Topic Classifications: |
| Analytical Science |
Drug Formulation & Delivery |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The aim of this project is to investigate the feasibility of using solution calorimetry to predict oral drug bioavailability and measure the effects of absorption-enhancing lipid-based formulations. Calorimetry has the unique ability to make quantitative in situ measurements of the processes that occur in simulated fed or fasted state intestinal fluid after the administration of a drug in a digestible lipid delivery vehicle. The heat of solution of model compounds in partially digested lipid formulations in simulated intestinal fluids will be compared to in vitro drug permeability data obtained using the same systems.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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