| EPSRC Reference: |
GR/R76035/02 |
| Title: |
High-resolution impedance imaging for materials charaterisation and life sciences applications |
| Principal Investigator: |
Krause, Professor S |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Materials |
| Organisation: |
Queen Mary University of London |
| Scheme: |
Advanced Fellowship (Pre-FEC) |
| Starts: |
01 March 2004 |
Ends: |
31 July 2008 |
Value (£): |
188,978
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| EPSRC Research Topic Classifications: |
| Biomaterials |
Materials Characterisation |
| Surfaces & Interfaces |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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A new imaging technique - Scanning Photo-induced Impedance Microscopy (SPIM) has been developed. It is capable of measuring the local impedance of thin films with good lateral resolution. Investigations of model systems have shown very promising results. In this programme, the resolution and the sensitivity of the new technique will be pushed to their limits in order to develop it into an attractive tool for the characterisation of the local properties of materials and biological systems. The applicant and her collaborators have identified potential applications of the imaging technique covering a wide range of different subject areas such as medicine, materials characterisation, membrane proteins and biosensors. SPIM will be used to investigate the process of melanoma invasion in reconstructed human skin models. The microstructure of tissue engineering scaffolds and the adhesion and spreading of cells on these materials will be studied. Other areas of application to be explored in this programme include the investigation of ion channel gating in pore proteins, which has implications for the development of new tools for drug screening, and the development of biosensor arrays capable of detecting proteases released at sites of inflammation and infection.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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