| EPSRC Reference: |
GR/R22247/01 |
| Title: |
Development of Novel Magnetic Force Bioreactors |
| Principal Investigator: |
Dobson, Professor J |
| Other Investigators: |
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| Department: |
Sch of Medicine |
| Organisation: |
Keele University |
| Scheme: |
Fast Stream |
| Starts: |
17 September 2001 |
Ends: |
16 May 2003 |
Value (£): |
62,205
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| EPSRC Research Topic Classifications: |
| Med.Instrument.Device& Equip. |
Tissue Engineering |
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Summary on Grant Application Form |
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Recent advances in bioreactor development are bringing many types of engineered tissue closer to the goal of normal clinical use. However, in the case of certain types of tissue (connective tissue in particular) major obstacles still exist. One of the primary difficulties in producing functional cartilage/bone structures is the inability to efficiently apply stresses during tissue growth in the bioreactor which reasonably mimic those experienced in vivo.To solve this problem, we propose to construct a novel magnetic force bioreactor system based on the physical principles of magnetism and magnetic materials. Spatially and temporally varying, high-gradient magnetic fields will be coupled to biocompatible magnetic micro- and nanoparticles within the bioreactor. The forces exerted on these particles will apply stress to the membranes of osteocytes and chondnxytes which have been seeded onto biodegradable scaffolds. These stresses can be varied in magnitude, space and time to produce optimal stresses for bone and cartilage growth as well as the growth of complex connective tissue structures. This system will offer numbers advantages over present systems such as: (i) the ability to easily change stress parameters, (ii) application of three-dimensional stress variations to single tissue constructs, (iii) allow the use of scaffolds with reduced mechanical properties.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.keele.ac.uk |