| EPSRC Reference: |
GR/M84398/01 |
| Title: |
SPRAY DRIED FORMULATIONS FOR THE PULMONARY DELIVERY OF PEPTIDES & PROTEINS |
| Principal Investigator: |
Brown, Professor M |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Pharmacy |
| Organisation: |
Kings College London |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
14 February 2000 |
Ends: |
13 May 2003 |
Value (£): |
52,871
|
| EPSRC Research Topic Classifications: |
|
| EPSRC Industrial Sector Classifications: |
| Manufacturing |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
|
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
The aim of this project is to investigate the applicability of using spray drying (SD) to produce chemically and biologically stable peptide/protein particles suitable for formulation in a dry powder aerosol for pulmonary delivery. Model proteins/peptides will be employed to investigate the effect of operating parameters and potential stabilisers on the particle characteristics and biological/chemical stability of SD protein/peptide formulations. chemical degradation of the protein/peptide will be analysed using LC and light scattering and bioactivity will be analysed using specific in vitro biological assays. The SD particles will be characterised according to particle size, shape, density, moisture content, thermal and flow properties. Determination of the effect of these properties on the pulmonary delivery of the SD protein/peptide particles will be performed in vitro using inertial impaction and pulmonary cell culture models developed in-house.Such a study can be expected to provide an extensive insight into the mechanisms of protein/peptide destabilisation during SD; identify possible means of improving stability during the SD process and subsequent storage and provide guidance for optimising the manufacturing protocols of solid proteins/peptides to achieve efficient pulmonary delivery. Should these objectives be achieved it could have wide range of scientific applications.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
|