| EPSRC Reference: |
GR/M78496/01 |
| Title: |
NOVEL OSTEO-INTEGRATIVE ORTHOPAEDIC BIOMATERIALS |
| Principal Investigator: |
Revell, Professor PA |
| Other Investigators: |
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| Department: |
Pathology |
| Organisation: |
UCL |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 April 2001 |
Ends: |
31 March 2003 |
Value (£): |
150,943
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| EPSRC Research Topic Classifications: |
| Biomaterials |
Tissue Engineering |
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| EPSRC Industrial Sector Classifications: |
| Healthcare |
Transport Systems and Vehicles |
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Summary on Grant Application Form |
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A major unresolved clinical problem in the management of orthopaedic conditions is the ability to implant orthopaedic prostheses, which achieve permanent fixation to surrounding bone. Presently, metal devices, whether cemented or non-cemented, show only poor osteointegration with a finite lifetime before loosening; porous ceramic coatings provide improvements but do not offer complete resolution. There therefore remains a clinical need to develop novel approaches to ensuring effective osteointegration of orthopaedic implants. The positioning of a biomaterial with a physical ultra-structure capable of forming a scaffold for osteogenic cell attachment between the (bone:implant) interface may be advantageous in promoting osteointegration. Previous research has shown that cells can be successfully grown in vitro in calcium-crosslinked alginate beads. This proposal therefore aims to investigate the use of calcium-cross linked carboxylated polysaccharides, such as calcium alginate and calcium pectinate in combination with other biodegradable and biocompatible polysaccharides such as chitosan for the production of a molecular scaffold for osteogenic cell attachment between the {bone:implant} interface to enhance osteo-integration for primary use within existing uncemented orthopaedic prostheses.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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