EPSRC logo

Details of Grant 

EPSRC Reference: EP/X027902/1
Title: Fluid dynamics of aggregation and attachment
Principal Investigator: Yeo, Ms E
Other Investigators:
Researcher Co-Investigators:
Project Partners:
University of Sheffield
Department: Mathematics
Organisation: UCL
Scheme: EPSRC Fellowship
Starts: 01 June 2023 Ends: 31 May 2026 Value (£): 333,586
EPSRC Research Topic Classifications:
Fluid Dynamics Particle Technology
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors
Related Grants:
Panel History:
Panel DatePanel NameOutcome
23 Nov 2022 EPSRC NFFDy Interview Panel 2022 Announced
02 Nov 2022 EPSRC NFFDy Prioritisation Panel 2 and 3 November 2022 Announced
Summary on Grant Application Form
Flow-mediated aggregation and attachment of microscale species to surfaces is pervasive in industrial, biological and pharmacological processes, ranging from bacterial colonisation of surgical implants to biomaterial manufacture. Since fluid stress and boundaries can alter the shape, swimming direction and biological function of bacterial cells and proteins, fluid flow can either promote or reduce aggregation. Continuum modelling is well suited to capture these processes over the length scales and timescales relevant to industrial systems and biological functions. However, continuum models which are not grounded in microscale processes are often unable to provide quantitative predictions.

In this fellowship, I will develop a framework to incorporate accurate flow-mediated microscale dynamics of fluid-responsive species into macroscale models of aggregating systems. I will apply this methodology to study two systems with timely relevance to industry and healthcare: biofilm formation in porous media and therapeutic protein aggregation during injection. This framework will be developed theoretically by first modelling attachment under shear in kinetic microscale continuum models, then exploring under which parameter regimes a mean-field description of the microscale dynamics can be reached. I will then incorporate these microscale continuum dynamics into macroscopic fluid models using homogenisation and asymptotic multiple scales analysis. These models which will be validated using experimental and microscale simulated data both at the microscale and macroscale and will then be used to predict ways of minimising clogging in both systems through control of flow parameters and device design.

This work will produce new theoretical advances in continuum modelling, as well as quantitative predictions to guide the treatment of antibiotic-resistant infections, manufacturing of therapeutic drugs and the delivery of vaccines, with beneficial impacts on millions of people worldwide.

Key Findings
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Potential use in non-academic contexts
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Description This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Date Materialised
Sectors submitted by the Researcher
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Project URL:  
Further Information:  
Organisation Website: