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Details of Grant 

EPSRC Reference: EP/N011554/1
Title: Imaging Cardio-Mechanical Health
Principal Investigator: Nordsletten, Dr D
Other Investigators:
Razavi, Professor R carr-white, Dr g Sinkus, Professor R
Chiribiri, Dr A
Researcher Co-Investigators:
Project Partners:
Department: Imaging & Biomedical Engineering
Organisation: Kings College London
Scheme: Standard Research
Starts: 04 January 2016 Ends: 03 January 2020 Value (£): 670,825
EPSRC Research Topic Classifications:
Med.Instrument.Device& Equip.
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
Panel History:
Panel DatePanel NameOutcome
01 Oct 2015 Engineering Prioritisation Panel Meeting 1 October 2015 Announced
Summary on Grant Application Form
Heart failure (HF) and coronary heart disease (CHD) are major clinical conditions affecting an estimated 2.7M people in the UK alone. Both of these conditions result in a fundamental reduction in the ability of heart muscle to effectively pump and deliver blood to the body. While this deficiency in the heart is easily detected using medical imaging, dissecting the causes of reduced heart performance in terms of its implications for muscle health remain an open challenge for the treatment of heart failure and evaluation of patient treatment.

The Imaging Cardiomechanical Health (ICMH) project aims to address this need by directly measuring the health of the heart muscle through the development of cardiac Magnetic Resonance Elastography (cMRE). Using state-of-the art magnetic resonance imaging and biomechanical modelling, this project will provide a novel noninvasive modality (cMRE) for directly measuring the alterations in muscle properties, determining the mechanical pathophysiology behind reduced function. Integrating new imaging sequences with biomechanical processing software, this project will aim to systematically develop, verify and validate these tools using 3D printed and ex vivo animal heart models. Building on these engineering developments, cMRE tools developed through the ICMH project will be applied in patients and volunteers to illustrate the potential of this new modality.

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