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Details of Grant 

EPSRC Reference: EP/L505328/1
Title: Guide Cardiac Resynchronisation Therapy - Guide CRT
Principal Investigator: Rhode, Dr KS
Other Investigators:
Razavi, Professor R
Researcher Co-Investigators:
Project Partners:
Department: Imaging & Biomedical Engineering
Organisation: Kings College London
Scheme: Technology Programme
Starts: 17 March 2014 Ends: 16 September 2017 Value (£): 454,212
EPSRC Research Topic Classifications:
Med.Instrument.Device& Equip.
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
Panel History:  
Summary on Grant Application Form
Cardiac Resynchronisation Therapy (CRT) has been shown to be a safe and effective treatment option in patients with

advanced drug-refractory Heart Failure (HF), systolic dysfunction and ventricular dyssynchrony. However, up to one-third of

patients implanted with a CRT device show no improvement in symptoms and up to half of patients show no improvement

in cardiac function. These non-responders are a strong burden to healthcare systems by causing considerable

unnecessary costs, e.g. for devices, implantations, recurring follow-up visits as well as hospitalisations for acute HF

decompensation The aim of this project is to develop a single platform which integrates all stages of the CRT pipeline,

referred to as the "Guide CRT", to improve response rate. The main components of this include MR clinical imaging

protocols dedicated to HF patients, tailored image processing tools (segmentation of the heart morphology, myocardial scar

and coronary sinus, as well as analysis of left ventricle (LV) wall motion), fused visualisation for improved patient selection

and planning of LV lead placement, and the image-based guidance technologies to support CRT device implantation.

Guide CRT will be evaluated on a cohort of 50 patients. Through the proposed joint efforts between leaders in their

respective industrial, academic and clinical fields, we aim to demonstrate that integrating comprehensive multimodal

imaging data and tools can help to provide answers to the great challenges of CRT, namely identification of patients who

are likely to respond and guiding LV lead placement to maximise this reponse.
Key Findings
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Potential use in non-academic contexts
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Impacts
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Summary
Date Materialised
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