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Details of Grant 

EPSRC Reference: EP/J010952/1
Title: Optical and Acoustic Imaging for Interventional Device Guidance
Principal Investigator: Desjardins, Dr A
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department: Medical Physics and Biomedical Eng
Organisation: UCL
Scheme: First Grant - Revised 2009
Starts: 13 March 2012 Ends: 12 March 2014 Value (£): 115,459
EPSRC Research Topic Classifications:
Instrumentation Eng. & Dev. Med.Instrument.Device& Equip.
Med.Instrument.Device& Equip. Medical Imaging
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
Panel History:
Panel DatePanel NameOutcome
13 Dec 2011 Materials, Mechanical and Medical Engineering Announced
Summary on Grant Application Form
Medical needles are central to a wide range of diagnostic and therapeutic interventions, including tissue biopsies and injections of anaesthesia. Accurately and efficiently reaching deep tissue targets can be very challenging. Many needle insertions are performed with ultrasound imaging systems that are exterior to the body, and with the sense of touch that is relayed via the needles to a physician's hands. These techniques are often insufficient for directly detecting the tissue targets, however, and consequently there is a risk of inaccurate needle placement. For instance, with biopsies of the prostate, the suspected cancerous lesions may not be visible with ultrasound imaging, and consequently the biopsies may be obtained from incorrect locations.

As a new Lecturer at the Department of Medical Physics and Bioengineering at UCL, one of my primary objectives is to transform medical needles so that they that can provide molecular information about tissue and thereby significantly improve the accuracy of needle-based procedures. Leveraging recent advances in optical telecommunications technologies, these needles will deliver brief light pulses to tissues at their tips. By virtue of the photoacoustic effect, absorption of light pulses will generate sound waves that can be detected and converted into images of molecular absorption in real-time. The research programme kick-started by an EPSRC First Grant will ultimately lead to the development of a broad range of medical devices that could directly detect tissue targets and critical structures to improve clinical outcomes and decrease the risks of complications.

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