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Details of Grant 

EPSRC Reference: EP/H024654/1
Title: In Vivo Reporting using Nanosystems Chemistry and Optical Spectroscopy
Principal Investigator: Graham, Professor D
Other Investigators:
Alexander, Professor J Brewer, Professor J Maffia, Professor P
Garside, Professor P Graham, Professor G Mottram, Professor JC
McInnes, Professor I Faulds, Professor KJ
Researcher Co-Investigators:
Project Partners:
Department: Pure and Applied Chemistry
Organisation: University of Strathclyde
Scheme: Standard Research
Starts: 01 April 2010 Ends: 31 March 2011 Value (£): 201,049
EPSRC Research Topic Classifications:
Biomaterials Cells
Drug Formulation & Delivery Med.Instrument.Device& Equip.
EPSRC Industrial Sector Classifications:
Related Grants:
Panel History:
Panel DatePanel NameOutcome
11 Sep 2009 Cross-Disciplinary Feasibility Account Announced
Summary on Grant Application Form
The research focus of this feasibility account is in the application of nanoscience into living systems for improvement of health. There are two themes which run through this research focussing on diagnostics and therapeutics. Our existing Platform Grant has allowed us to start looking at functionalised nanoparticles as responsive nanosensors for analysing cell receptors and enzyme activity within cells based on the change in surface enhanced Raman scattering in a number of target systems. The focus so far has been on immunologically compromised cells and, through very exciting preliminary data and discussion with interested, more clinically based parties, we propose to use this feasibility account to allow us to conduct preliminary studies transposing our research to the next level and to that of genuine in vivo experimentation and implementation of nanoscience. So far, the focus has been on diagnostic information retrieval however, here we propose to couple this with a therapeutic aspect. The mounting of biological drugs, such as therapeutic antibodies, onto nanoparticles appears to have significant effect on the efficacy of the drug when used in vitro. To test this in vivo is very challenging and largely an unknown entity. New biological drugs that have been developed are not fully characterised in terms of where they locate within a body and where they provide their most beneficial action. Despite this, FDA approval has been given and we propose to use our combination of nanoscience, spectroscopy functionalisation and immunological/clinical expertise to create a series of cross disciplinary highly adventurous in vivo experiments with a view to pump priming a much larger and consolidated programme of work.
Key Findings
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Potential use in non-academic contexts
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Date Materialised
Sectors submitted by the Researcher
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Project URL:  
Further Information:  
Organisation Website: http://www.strath.ac.uk