Details of Grant 

EPSRC Reference:	EP/C548264/1
Title:	Interdisciplinary Research Network : in situ Functional Proteomic Technology
Principal Investigator:	Irving, Professor M
Other Investigators:	Richards, Professor D Ng, Professor T
Researcher Co-Investigators:
Project Partners:
Department:	GKT School of Biomedical Sciences
Organisation:	Kings College London
Scheme:	Standard Research (Pre-FEC)
Starts:	15 August 2005	Ends:	14 November 2008	Value (£):	62,755
EPSRC Research Topic Classifications:	Biological & Medicinal Chem. Chemical Structure Genomics Lasers & Optics
EPSRC Industrial Sector Classifications:	Healthcare
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Summary on Grant Application Form
The proteomics research network will form a UK centre of excellence for the development of radical new technologies to address the major outstanding challenges in our understanding of the function of proteins. Non-invasive analysis of intact/live biological cells is made possible by employing techniques based on the use of light. This will enable the study of protein function within a true biological context, not possible with existing approaches. A high speed implementation of these technologies on large numbers of assays will provide a specific probe of biological cause and effect involving protein function, and enable a determination of the ways in which a chain of events involving different proteins can result in specific physiological responses to external stimuli. Optical technology development will focus on techniques for high-speed reliable imaging and methods for the detection of protein events occurring specifically on the surface of a cell, the location of the majority of 'biosensors'for environmental changes. We will also develop gene libraries encoding all possible genomic sequences, and new chemical approaches for the attachment of molecular units for the optical detection of events involving proteins. These new proteomic technologies will be used to address a number of important current issues, including stem cells, cancer, allergy and asthma. The proposed network will serve to bring together the multidisciplinary and multiinterdisciplinary consortium of researchers required for the realisation of this research vision.
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