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Details of Grant 

EPSRC Reference: EP/C546105/1
Title: Optical Proteomic Technology for In-Situ Analysis of Protein Interaction Networks
Principal Investigator: Irving, Professor M
Other Investigators:
Heintzmann, Dr R Richards, Professor D Suhling, Professor K
Ng, Professor T
Researcher Co-Investigators:
Project Partners:
Centre de Recherches INSERM
Department: Sch of Biomolecular Sciences
Organisation: Kings College London
Scheme: Standard Research (Pre-FEC)
Starts: 24 October 2005 Ends: 23 February 2010 Value (£): 1,000,300
EPSRC Research Topic Classifications:
Analytical Science Genomics
Lasers & Optics
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors
Related Grants:
EP/C546113/1
Panel History:  
Summary on Grant Application Form
The proteomics research programme will aim at the development of radical new technologies to address the major outstanding challenges in our understanding of the functional interactions of proteins. Non-invasive analysis of intact/live biological cells is made possible by optical techniques . This will enable the study of protein function within a truebiological context, which is not possible with existing approaches. A high-speed high-throughput implementation of the new technologies will allow the extended network of protein-protein interactions that regulate cell function and determine specific physiological responses to be unravelled. Optical technology development will focus on robust high-speed imaging and methods for the detection of protein interactions occurring specifically on the cell surface, which offers many potential drug targets. These new proteomic technologies will benefit a number of important biomedical issues, including stem cells, cancer, allergy and asthma. This research programme builds on the availability of the human genome to bridge the gap between advanced optical cell imaging, cell biology and clinical medicine.
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