| EPSRC Reference: |
EP/C519825/1 |
| Title: |
Digital Molecular Information Layers for Sensors and Diagnostics |
| Principal Investigator: |
Badyal, Professor JP |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Chemistry |
| Organisation: |
Durham, University of |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 December 2004 |
Ends: |
30 November 2005 |
Value (£): |
100,823
|
| EPSRC Research Topic Classifications: |
|
| EPSRC Industrial Sector Classifications: |
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
A method is described for screening molecular recognition using a conventional compact disk (CD) player. The procedure comprises inkjet printing tracks of ligands to produce a digital molecular information layer onto the reading face of a plasmachemically functionalized compact disk. The wide-scale applicability of these digital molecular information layers will be demonstrated for sequence selective DNA detection (something which is important for unravelling the genetic basis of disease). This rapid screening will rely upon the specific hybridization of surface-bound, single strand capture oligonucleotides to complementary targets. Individual biomolecule recognition events will be read using error determination and visualization software routines developed during the project. Compared to all existing approaches for DNA assays, this method is estimated to be several orders of magnitude cheaper and quicker. Therefore making it a likely candidate for adoption by forensic laboratories, hospitals, and doctors surgeries for routine genetic/medical diagnosis using existing desktop computers. To facilitate the latter suitable software needs to be developed following acceptable software engineering guideline together with tailored visualisations of the results.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
|