EPSRC Reference: |
GR/T22858/01 |
Title: |
Multiple-fibre reconstruction in diffusion MRI |
Principal Investigator: |
Alexander, Professor D |
Other Investigators: |
|
Researcher Co-Investigators: |
|
Project Partners: |
|
Department: |
Computer Science |
Organisation: |
UCL |
Scheme: |
Standard Research (Pre-FEC) |
Starts: |
11 April 2005 |
Ends: |
10 April 2008 |
Value (£): |
290,995
|
EPSRC Research Topic Classifications: |
Biomedical neuroscience |
Image & Vision Computing |
|
EPSRC Industrial Sector Classifications: |
Healthcare |
Information Technologies |
|
Related Grants: |
|
Panel History: |
|
Summary on Grant Application Form |
This work will develop anew generation of computer program for processing diffusion MRI scans of the brain. Diffusion MRI measures the random thermal movement (diffusion) of water molecules in brain tissue. White matter in the brain consists of bundles of axon fibres and is the electrical cabling that connects different brain regions. Water molecules move further along the fibres than across them, because they cannot pass through the fibre walls. Computer programs that process diffusion MRI measurements estimate the direction of fibres at each position in the brain by looking for directions in which water molecules move furthest. Once the fibre directions are known, we can follow them from point to point through the brain and map the connectivity between regions. Connectivity maps like this have opened new doors to the understanding of brain architecture, development and disease. Diffusion-tensor MRI is the program used routinely in diffusion MRI. This program estimates only a single fibre direction at each point. However, brain tissue is complex and fibres cross in many important areas. The new programs we will develop will reveal the directions of multiple crossing fibres. This extra information will greatly improve the quality of our connectivity maps and provide greater insight into the workings of the brain.
|
Key Findings |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
Potential use in non-academic contexts |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
Impacts |
Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
Summary |
|
Date Materialised |
|
|
Sectors submitted by the Researcher |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
Project URL: |
|
Further Information: |
|
Organisation Website: |
|