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Details of Grant 

EPSRC Reference: GR/T29161/01
Title: Fundamental aspects of the electronic structure of biointeractions using high performance electron spectroscopy
Principal Investigator: Williams, Professor R
Other Investigators:
Haines, Dr SR Beamson, Dr G Weightman, Professor P
Researcher Co-Investigators:
Project Partners:
Department: School of Engineering
Organisation: University of Liverpool
Scheme: Postdoctoral Mobility PreFEC
Starts: 01 October 2004 Ends: 30 September 2005 Value (£): 72,114
EPSRC Research Topic Classifications:
Biomaterials Surfaces & Interfaces
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
Panel History:  
Summary on Grant Application Form
The interactions of proteins with biomateral surfaces play a key role in the cellular response to and hence success of implanted devices. This project will use high performance electron spectrometers including a newly developed high-energy X-ray source to probe the fundamental properties of these interactions.The high-energy X-ray source developed on the Scienta ESCA300 spectrometer at the National Centre for Electron Spectroscopy and Surface Analysis (NCESS) at Daresbury makes it possible to make high resolution x-ray photoelectron measurements on the deep core levels of elements that could not be studied previously. The research will also use a high performance Auger spectrometer in Liverpool. The experimental results will be analysed by applying state of the art theoretical treatments in order to obtain a fundamental insight into the bonding of proteins to biomaterial surfaces. This will facilitate the adaptation or design of biomaterials in order to improve their biocompatibility.This project brings together an interdisciplinary team with knowledge and experience of the development of biomaterials and with state of the art electron spectrometers together with expertise in the analysis of electron spectroscopy results in terms of fundamental theoretical concepts. This combination of the practical knowledge of biomaterials, high performance instrumentation and insight into fundamental determinants of electronic structure is ideally suited to the development of a fundamental understanding of the interactions between proteins and the surfaces of biomaterials.
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Further Information:  
Organisation Website: http://www.liv.ac.uk