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Details of Grant 

EPSRC Reference: GR/T26542/01
Title: Probing the Glycosidic Linkage
Principal Investigator: Davis, Professor B
Other Investigators:
Clary, Professor Sir D Snoek, Dr LC Simons, Professor JP
Researcher Co-Investigators:
Project Partners:
Department: Oxford Chemistry
Organisation: University of Oxford
Scheme: Standard Research (Pre-FEC)
Starts: 01 April 2005 Ends: 30 September 2009 Value (£): 633,238
EPSRC Research Topic Classifications:
Biological & Medicinal Chem. Carbohydrate Chemistry
Chemical Biology Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:
Pharmaceuticals and Biotechnology
Related Grants:
Panel History:  
Summary on Grant Application Form
We present a new and exciting coordinated research programme linking chemical biology, chemical physics and glycobiology. It involves a combination of molecular synthesis, to create the key `building blocks' in a range of target oligosaccharides and their glyco-conjugates; infrared laser spectroscopy over a very broad spectral range, to probe their 'vibrational signatures'- free of the environment, or interacting with it in a controlled way within `custom-made' molecular complexes; and computational chemistry, including the development of new theoretical methods, to translate these into their molecular and conformational structures and determine their relative energies and free energies. A direct route to the future determination of inter-conformer barrier heights, and molecular flexibility is offered by the recent discovery of vibrationally-promoted, conformational inter-conversion.
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Further Information:  
Organisation Website: http://www.ox.ac.uk