| EPSRC Reference: |
GR/T26542/01 |
| Title: |
Probing the Glycosidic Linkage |
| Principal Investigator: |
Davis, Professor B |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Oxford Chemistry |
| Organisation: |
University of Oxford |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 April 2005 |
Ends: |
30 September 2009 |
Value (£): |
633,238
|
| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Carbohydrate Chemistry |
| Chemical Biology |
Chemical Synthetic Methodology |
|
| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
|
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
We present a new and exciting coordinated research programme linking chemical biology, chemical physics and glycobiology. It involves a combination of molecular synthesis, to create the key `building blocks' in a range of target oligosaccharides and their glyco-conjugates; infrared laser spectroscopy over a very broad spectral range, to probe their 'vibrational signatures'- free of the environment, or interacting with it in a controlled way within `custom-made' molecular complexes; and computational chemistry, including the development of new theoretical methods, to translate these into their molecular and conformational structures and determine their relative energies and free energies. A direct route to the future determination of inter-conformer barrier heights, and molecular flexibility is offered by the recent discovery of vibrationally-promoted, conformational inter-conversion.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.ox.ac.uk |