| EPSRC Reference: |
GR/T21578/01 |
| Title: |
New Catalytic Reactions for the Formulation of Heterocyles |
| Principal Investigator: |
Donohoe, Professor T |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Oxford Chemistry |
| Organisation: |
University of Oxford |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 February 2005 |
Ends: |
31 January 2007 |
Value (£): |
126,183
|
| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Catalysis & Applied Catalysis |
| Chemical Synthetic Methodology |
|
|
| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
The development of new catalytic procedures is one of the most pressing goals for modern synthetic organic chemistry because chemical industry has an ever increasing requirement for selective, efficient and environmentally friendly chemical processes.This work describes the development of a novel catalytic reaction and allows the formation of complex, stereochemically defined heterocycles to be produced in one step from linear precursors. The heterocycles that are thus produced have lots of (proven) interesting applications in organic chemistry primarily as the key constituents of biologically active compounds.Importantly, this new reaction allows us to prepare heterocycles as single enantiomers which gives it a distinct new direction that will yield interesting and powerful results.By investigating and understanding how this new catalytic reaction works we shall gain insight into new aspects of organic and inorganic reactivity and by combining the two we should be able to produce a powerful new technique for making heterocycles containing both oxygen and nitrogen.The usefulness of our reaction will also be extended by a thorough study into methods for ring expanding the products that we obtain so as to produce very highly functionalised six and seven membered rings; in the longer term application of our new methodology to synthesis will follow.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.ox.ac.uk |