| EPSRC Reference: |
GR/T20120/01 |
| Title: |
The Catalytic Enantioselective Synthesis of Quaternary Carbon Centres |
| Principal Investigator: |
Willis, Professor M |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Bath |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 January 2005 |
Ends: |
31 December 2006 |
Value (£): |
121,899
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| EPSRC Research Topic Classifications: |
| Asymmetric Chemistry |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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The efficient and stereoselective construction of quaternary carbon centres remains a formidable challenge to synthetic organic chemists. In this project a new strategy for the synthesis of these important structural motifs, based on enantioselective desymmetrization, is developed. The key reactions are a family of related enantioselective palladium catalysed cross-coupling processes. The early part of the project is concerned with the identification and optimization of the best catalyst and ligand system for a prototype reaction. The effects of the structure of the substrate on both the selectivity and efficiency of the process will then be examined. The final section of the research will focus on developing new reactions that can be employed in the process so that variously substituted products confining the key quaternary centre can be prepared. On completion of the project a new, useful, robust synthetic method will have been developed.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bath.ac.uk |