| EPSRC Reference: |
GR/T09705/01 |
| Title: |
Designing Porous Metal-Organic Frameworks to Store and Deliver Large Amounts of Nitric Oxide |
| Principal Investigator: |
Morris, Professor RE |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of St Andrews |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 December 2004 |
Ends: |
31 January 2008 |
Value (£): |
186,022
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
Drug Formulation & Delivery |
| Energy Storage |
Medical science & disease |
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| EPSRC Industrial Sector Classifications: |
| Healthcare |
Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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Nitric oxide (NO) is an amazing Jekyll and Hyde compound. We go to great lengths to remove NO from the exhaust gases of automobiles as it is a harmful pollutant. However, nitric oxide is also extremely important in mammalian biology. It is implicated in many processes in the body including vasodilation, the prevention of platelet aggregation and thrombus formation, neurotransmission and wound repair. There are tremendous possibilities for the use of NO in prophylactic and therapeutic processes, including potential applications in anti-thrombogenic medical devices, improved dressings for wounds and ulcers and the treatment of fungal and bacterial infections (amongst many many others). It is predicted that the global market for treatments that involve NO will rise to-US$100 bn by 2010.Unfortunately, because of its gaseous nature, it is difficult to deliver NO in controlled amounts to areas of specific need. There is a great need to design materials that can store and release large amounts of NO, which can then be used in medical applications. In this project we will design new materials based on metal organic frameworks with the right chemical characteristics to allow high storage capacity. We will prepare new materials that have two different sites for NO storage (and a mixture of both) and we will thoroughly characterise the materials to find their structure and their NO release properties. We will then test the materials to show their biological activity. The biological testing will involve three main strands; a study of the pharmacology and mechanism of action of the materials in human platelets and monocytes, an in vitro assessment of platelet and rrnonocyte adhesion and an in vivo assessment of anti-clotting effects of the materials.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.st-and.ac.uk |