| EPSRC Reference: |
GR/T09583/01 |
| Title: |
Carbon-carbon and carbon-heteroatom bond formation catalysed by palladium-carbene complexes |
| Principal Investigator: |
Caddick, Professor S |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
UCL |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 December 2004 |
Ends: |
30 November 2007 |
Value (£): |
227,212
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| EPSRC Research Topic Classifications: |
| Catalysis & Applied Catalysis |
Co-ordination Chemistry |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
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Summary on Grant Application Form |
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We propose to build on exciting preliminary work in which we have used a combination of synthetic, structural and mechanistic chemistry to further our understanding of novel classes of organopalladium compounds as catalysts for organic synthesis. In this project we will exmine three distinct classes of organic transformation each of which offer clean effective routes to organic molecules of interest to the synthetic community. Specifically we will examine the ability of novel palladium(NHC) complexes to catalyse amination reactions of aryl chlorides. We will develop and extend our recent findings on the intramolecular Heck reactions using aryl chlorides to define optimal conditions and to delineate the scope and limitations of this protocol. In the final part of the project we propose to examine new reactions of alkyl halides using substrates containing beta-hydrogens, this is an important academic problem with great potential for applications in industry and academia. We will examine the potential for carrying out the intermolecular Suzuki reaction and most speculatively the intramolecular Heck reaction. Success in these areas will lead to efficient and cleaner approaches to the synthesis of functionalised and polycyclic structures on which many organic synthesis and medicinal chemistry projects are based.Throughout the project we will attenpt to provide structural evidence for intermediates along the catalytic pathway to provide a firm basis on which mechanistic rationale and further catalyst design can be based.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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