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Details of Grant 

EPSRC Reference: GR/T08746/01
Title: Spectroscopic Imaging for High-Throughput Analysis
Principal Investigator: Kazarian, Professor SG
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Bruker Pfizer Surface Measurement Systems
UCL
Department: Department of Chemical Engineering
Organisation: Imperial College London
Scheme: Standard Research (Pre-FEC)
Starts: 05 October 2004 Ends: 04 April 2006 Value (£): 101,603
EPSRC Research Topic Classifications:
Analytical Science Drug Formulation & Delivery
Materials Characterisation
EPSRC Industrial Sector Classifications:
Chemicals Pharmaceuticals and Biotechnology
Related Grants:
Panel History:  
Summary on Grant Application Form
We propose to develop a novel imaging approach for parallel analysis of pharmaceutical formulations under controlled environment. FTIR imaging is based on a 64x64 element infrared array detector which allows simultaneous measurements of 4096 spectra from different locations in a sample. In principal, this also allows simultaneous screening of many (up to 4096) different samples. We have recently successfully combined FTIR imaging system with various ATR-IR spectroscopic accessories for imaging of specific samples. In the proposed project, the ATR-IR crystals will be modified such that the surface is covered with a patterned grid where each element of the grid serves as a cell for a small quantity of a sample. The cell will be enclosed and combined with a device that controls the relative humidity inside the cell. Using this approach, it will be possible to obtain chemical snapshots from a spatially-defined array of many different samples under identical conditions, thus providing direct measurement of materials properties for high-throughput formulation design and optimisation. The simultaneous response (plasticisation, swelling, crystallisation, dissolution, polymorphic changes, etc.) of the array of many samples to the environmental parameters (temperature, humidity, etc.) will be studied. This miniature multi-channel system will represent the first rapid parallel screening approach of its type with broad implications for pharmaceuticals, polymers and controlled release systems. The overall aim is to develop universal high-throughput imaging approach with broad range of industrial applications.
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Organisation Website: http://www.imperial.ac.uk