| EPSRC Reference: |
GR/T07527/01 |
| Title: |
Reactive Plasma Polymers for Micropatterned Bioarrays |
| Principal Investigator: |
McArthur, Professor SL |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Materials Science and Engineering |
| Organisation: |
University of Sheffield |
| Scheme: |
First Grant Scheme Pre-FEC |
| Starts: |
28 September 2004 |
Ends: |
27 September 2007 |
Value (£): |
127,735
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| EPSRC Research Topic Classifications: |
| Genomics |
Materials Characterisation |
| Materials Synthesis & Growth |
Medical science & disease |
| Surfaces & Interfaces |
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| EPSRC Industrial Sector Classifications: |
| Healthcare |
Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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Microarray-based protein and cell assays are an integral element in the detection and diagnosis of disease, discovery and development; of drugs, proteomics and genomics. Bioarrays offer a number of advantages over the traditional assays including: simultaneous anal, of multiple parameters within a single experiment and significant reductions in the amounts of material required to perform an assay At present biological microarray technology is being hampered by problems linked to the surface chemistry of the devices. While a large number of techniques exist for the preparation of protein and cellular microarrays, plasma polymerisation presents a versatile, rapid and environmentally sound approach to surface modification of these devices. Unlike the silane and alkane thiol chemistries typically used for bioarray surfaces, plasma polymerisation can be use on virtually any substrate to produce thin adherent coatings i1 specific physicochemical properties. It is a dry, sterile process that produces little residue and the selection of surface chemical characteristics is limited only by the requirement that the monomer be in the vapour phase. This project addresses methods for the precise control of microarray surface chemistry that will enable micron-scale patterning of a bioactive array on a non-fouling substrate to produce spotted bioarrays with improved sensitivity and selectivity.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.shef.ac.uk |