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Details of Grant 

EPSRC Reference: GR/T05011/01
Title: Functional group reduction: Developing a better understanding of electron transfer
Principal Investigator: Donohoe, Professor T
Other Investigators:
Compton, Professor R
Researcher Co-Investigators:
Project Partners:
Department: Oxford Chemistry
Organisation: University of Oxford
Scheme: Standard Research (Pre-FEC)
Starts: 01 October 2004 Ends: 30 September 2007 Value (£): 194,819
EPSRC Research Topic Classifications:
Chemical Synthetic Methodology Electrochemical Science & Eng.
EPSRC Industrial Sector Classifications:
Chemicals Pharmaceuticals and Biotechnology
Related Grants:
Panel History:  
Summary on Grant Application Form
This proposal charts a collaborative project whereby two aspects of the reduction process will be studied in collaboration by two research groups. The sum total of our efforts will be greater than that which we could achieve individually.T. J. Donohoe will investigate the synthetic aspects of the reduction process using both homo- and heterogeneous reducing conditions. The idea is to build up a picture of the relative reactivity of a broad range of functional groups so that advanced synthetic work can be undertaken. By perfoming competition experiments, we will be able to group organic functionality according to its reactivity. This reactivity may also be tuneable depending on the reducing conditions employed and selective reduction and electron transfer processes will follow.R. Compton will investigate the mechanistic ramifications of the reduction process using a variety of techniques, ranging from electrochemistry to electron spin resonance. By understanding the exact details of the reduction process, as applied to organic compounds, we will be able to develop new functional groups that are either very robust or very labile to electron reduction.
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Organisation Website: http://www.ox.ac.uk