Details of Grant 

EPSRC Reference:	GR/S87218/01
Title:	Using Hydrogen Bonds to make New Asymmetric
Principal Investigator:	Clarke, Professor ML
Other Investigators:
Researcher Co-Investigators:
Project Partners:	DSM
Department:	Chemistry
Organisation:	University of St Andrews
Scheme:	First Grant Scheme Pre-FEC
Starts:	01 September 2004	Ends:	31 August 2006	Value (£):	118,026
EPSRC Research Topic Classifications:	Asymmetric Chemistry Catalysis & Applied Catalysis
EPSRC Industrial Sector Classifications:	Chemicals Pharmaceuticals and Biotechnology
Related Grants:
Panel History:
Summary on Grant Application Form
There are severe time restrictions for methodology development in the pharmaceutical industry. A major demand in this industry (and in organic synthesis in general) is the preparation of enantiomerically pure compounds. Although the use of asymmetric catalysts will often represent the most efficient, environmentally friendly and even (once the process is up and running) the most cost effective method to deliver single enantiomer compounds, they are still rarely used as a result of the considerable amount of time needed to identify the ideal catalyst for the reaction under study. Consequently, there has been ever expanding interest in the rapid synthesis and screening of libraries of ligands in asymmetric catalysis.This project aims to develop a new approach towards rapidly obtaining diversity within chiral catalysts. A chiral transition metal complex containing a network of hydrogen bonds that are capable of recognising and binding a library of complementary achiral additives will be prepared. These will be used as enantioselective catalysts for several important asymmetric reactions. The approach will allow a library of distinct chiral catalysts to self assemble from a single chiral pre-catalyst immediately prior to their screening in an enantioselective reaction. The successful implementation of this protocol will be reminiscent of an adjustable spanner or socket set used by mechanics to undo a variety of different shaped nuts and bolts: In catalysis, a different additive will be the optimal fit for each different reaction or substrate.
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Organisation Website:	http://www.st-and.ac.uk