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Details of Grant 

EPSRC Reference: GR/S85351/02
Title: Development of the Generic Picotitre Plates Employing Reagentless 3D Multi Parametric Detection
Principal Investigator: Davis, Professor J
Other Investigators:
Compton, Professor R Hay, Professor J Livingstone, Dr C
Researcher Co-Investigators:
Project Partners:
Department: School of Science & Technology
Organisation: Nottingham Trent University
Scheme: Standard Research (Pre-FEC)
Starts: 01 April 2005 Ends: 31 July 2007 Value (£): 211,853
EPSRC Research Topic Classifications:
Analytical Science Chemical Biology
EPSRC Industrial Sector Classifications:
Healthcare Pharmaceuticals and Biotechnology
Related Grants:
Panel History:  
Summary on Grant Application Form
High throughput screening systems have traditionally utilised a well type approach into which the reagents necessary for the unambiguous detection of a single analyte are loaded. Broad spectrum screening can be achieved through loading different wells with different indicating reagents but this necessitates the adoption of high density formats and can require a significant amount of sample volume to be distributed within the various wells. The proposed project adopts a novel approach in which multiple analytes can be detected within a single well. This can achieved through the integration of reagentless electrochemical sensor arrays embedded within the walls of the sample well rather than the single colorimetric/fluorimetric probes currently used in spectroscopic scanning. This reduces the sample volume required for screening with the potential for reagentless sensing offering the possibility of repeated / continuous detection applications. The project will assess the practicalities of locating different types of sensor within the well architecture and develop new techniques that can enable the retention of sensor activity and which can be employed in sequence to dramatically improve sensitivity. The analytical and clinical efficacy of utilising the prototype plates for the broad spectrum screening of physiological samples will be compared against conventional techniques.
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Organisation Website: http://www.ntu.ac.uk