| EPSRC Reference: |
GR/S81834/01 |
| Title: |
MRI of Hyperpolarised 3Helium Gas At High Magnetic Field Strengths |
| Principal Investigator: |
Wild, Professor J |
| Other Investigators: |
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| Department: |
Medicine and Biomedical Science |
| Organisation: |
University of Sheffield |
| Scheme: |
First Grant Scheme Pre-FEC |
| Starts: |
06 September 2004 |
Ends: |
05 September 2007 |
Value (£): |
122,740
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| EPSRC Research Topic Classifications: |
| Med.Instrument.Device& Equip. |
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Summary on Grant Application Form |
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MRI of hyperpolarised (HP) Helium-3 (3He) shows much promise for imaging the pulmonary air spaces. Although the overall spin density of gas in the lungs is low, the process of hyperpolarisation of the nuclear spin population (with optical pumping) compensates giving sufficient signal for MR imaging when the gas is inhaled in-vivo. The focus of this work will be the optimisation of signal to noise, spatial resolution and temporal resolution in the methodology for magnetic resonance imaging of inhaled HP3He Gas. The research will be performed on a whole body research MRI scanner at a magnetic field strength of 1.5T and will include development of prospective pulse sequence designs and radio frequency hardware for parallel imaging methods. The developed methods will help reduce the amounts of gas needed in imaging through optimisation of polarisation usage. This is important if 3He MRI is to become widely used in the future since 3He is an expensive and limited resource. The aim is to image, with as high spatial resolution as possible, ventilation of gas in the human lung in three dimensions without the use of harmful ionising radiation as is currently used in the clinical standard lung imaging modality - nuclear scintigraphy.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.shef.ac.uk |