| EPSRC Reference: |
GR/S79305/01 |
| Title: |
Enantiopure versus Conformationally Flexible NUPHOS Diphosphines: A Comparative Study of their Performance in Platinum Group Asymmetric Catalysis |
| Principal Investigator: |
Doherty, Dr S |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
School of Chemistry |
| Organisation: |
Newcastle University |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
31 March 2005 |
Ends: |
29 September 2008 |
Value (£): |
109,635
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| EPSRC Research Topic Classifications: |
| Asymmetric Chemistry |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
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| Panel History: |
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Summary on Grant Application Form |
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We have recently developed the synthesis of an entirely new class of diphosphine, NUPHOS, a four carbon bridged diphosphine that forms highly active catalysts for Kumada cross coupling reactions. The primary objective of this project is to prepare a range of enantiopure chiral NUPHOS type diphosphines, investigate their coordination chemistry and explore their applications in platinum group asymmetric catalysis. Where appropriate the synthesis will be guided by molecular modelling studies that will be used to determine the relative energies of the diastereoisomeric conformations and the barrier to their interconversion. Where possible, this process of atropinversion (interconversion of chiral conformations) will be studied by NMR to determine the activation barrier and the factors that influence the energy of this process. The basic ligand structure will be modified to examine the influence of steric and electronic factors on catalyst performance. The process of atropinversion (interconversion of chiral conformations) will be studied to determine the activation barrier and the factors that influence the energy of this process. The results of these studies will be evaluated against those obtained in a parallel project undertaken at Queens University, which will develop conformationally flexible, tropos versions of NUPHOS.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ncl.ac.uk |