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Details of Grant 

EPSRC Reference: GR/S79268/01
Title: Glycochips-strategies for high-throughput analysis of the glycome
Principal Investigator: Flitsch, Professor S
Other Investigators:
Turnbull, Professor J Gouverneur, Professor V Crocker, Professor PR
Russell, Professor D Field, Dr R Haslam, Professor SM
Davis, Professor B Dell, Professor A Feizi, Professor T
Donohoe, Professor T Fairbanks, Professor AJ
Researcher Co-Investigators:
Project Partners:
Department: Sch of Chemistry
Organisation: University of Edinburgh
Scheme: Standard Research (Pre-FEC)
Starts: 01 May 2004 Ends: 30 July 2005 Value (£): 3,570,609
EPSRC Research Topic Classifications:
Biological & Medicinal Chem. Carbohydrate Chemistry
Chemical Biology Combinatorial Chemistry
Genomics
EPSRC Industrial Sector Classifications:
Healthcare Pharmaceuticals and Biotechnology
Related Grants:
Panel History:  
Summary on Grant Application Form
Carbohydrate-protein interactions are critical in many important biological events, in particular on cell surfaces. The aim of the present project is to develop carbohydrate arrays (glycochips) as innovative tools to map out the carbohydrate and protein partners in these biologically important interactions of the glycome (the complete set of carbohydrate structures produced by a particular cell or tissue). The project brings together a diverse set of novel technologies in the generation of carbohydrate microarrays (from natural sources, by chemical and enzymatic synthesis), in high throughput expression of carbohydrate binding proteins and in the analyses of binding proteins through mass spectrometry. An understanding of the cell's glycomeprotein interactions complements data from studies of the proteome (protein-protein interactions) and represents an essential facet post-genome technology development that will underpin exploitation through development of novel glycotherapeutics in diverse applications such as malignant disease, viral and bacterial infections, inflammation, innate and acquired immunity, neurodegeneration, wound healing and tissue engineering.
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Organisation Website: http://www.ed.ac.uk