| EPSRC Reference: |
GR/S77455/01 |
| Title: |
Intermolecular Hydroacylation: A New Reaction for Organic Synthesis |
| Principal Investigator: |
Willis, Professor M |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Bath |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 April 2004 |
Ends: |
31 December 2006 |
Value (£): |
178,449
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| EPSRC Research Topic Classifications: |
| Catalysis & Applied Catalysis |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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The hydroacylation of alkenes is an example of a growing number of transformations based on C-H bond activation. The transformation has the potential to be a powerful synthetic tool; it is promoted by a number of transition metal catalysts and is inherently atom-economic. The utility of the reaction is limited by the propensity of the key acyl-metal intermediates to undergo decarbonylation, producing reduced substrates and inactive catalysts.In this proposal we detail a new approach to intermolecular hydroacylation utilizing the stabilizing ability of a pendent heteroatom to allow the direct addition of alkyl aldehydes to a range of functionalised alkenes under mild conditions using low catalyst loadings. The key to developing a successful system is the formation of chelation stabilised acyl-metal intermediates. The basic reactivity will initially be studied, before investigations into diastereoselective and enantioselective processes are undertaken. A method of employing alcohol substrates directly in the process will also be investigated.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bath.ac.uk |