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Details of Grant 

EPSRC Reference: GR/S77370/01
Title: Mid-infrared optical coherence tomography of engineered tissues in bioreactors
Principal Investigator: Cockburn, Professor J
Other Investigators:
Hopkinson, Professor M Wilson, Dr LR
Researcher Co-Investigators:
Project Partners:
Department: Physics and Astronomy
Organisation: University of Sheffield
Scheme: Standard Research (Pre-FEC)
Starts: 11 October 2004 Ends: 10 April 2008 Value (£): 211,591
EPSRC Research Topic Classifications:
Chemical Biology Med.Instrument.Device& Equip.
Tissue Engineering
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
GR/S77356/01
Panel History:  
Summary on Grant Application Form
We propose to develop a novel imaging instrument for monitoring the distribution of biochemical species within laboratory-grown tissues at specific midinfrared wavelengths. The instrument is intended to satisfy the urgent need of tissue engineers for real-time sensors to guide the development of tissues grown in bioreactors. A free-space two-beam interferometer will be constructed to perform optical coherence tomography on tissues using custom-built quantum cascade lasers with short coherence lengths. The device will facilitate real-time imaging of musculo-skeletal tissue-engineered constructs during growth at a resolution of a few tens of microns. Images will highlight the characteristic absorption at mid-infrared wavelengths by collagen amide, and phosphate and carbonate compounds in bone. This will enable both normal and pathological tissue function to be observed, and the growth of tissue to be controlled and directed through non-invasive measurement of the metabolism and morphology of cells during all phases of the growth cycle.
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Further Information:  
Organisation Website: http://www.shef.ac.uk