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Details of Grant 

EPSRC Reference: GR/S76892/01
Title: Dynamic combinatorial chemistry
Principal Investigator: Sanders, Professor J
Other Investigators:
Otto, Professor S
Researcher Co-Investigators:
Project Partners:
Department: Chemistry
Organisation: University of Cambridge
Scheme: Standard Research (Pre-FEC)
Starts: 01 March 2004 Ends: 30 September 2007 Value (£): 1,093,157
EPSRC Research Topic Classifications:
Combinatorial Chemistry
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors
Related Grants:
GR/S76908/01
Panel History:  
Summary on Grant Application Form
Our previous work has demonstrated that dynamic combinatorial chemistry can be a practical tool for the identification and synthesis of new receptors. We now propose to exploit dynamic combinatorial chemistry further. Using mupltiply-functionalised building blocks we will specifically target new receptors with levels of complexity that are very hard to handle using alternative approaches. We aim to achieve hydrogen bonding as a recognition motif in water. By exploiting the chirality of the building blocks we hope to be able to discover new enantioselective receptors. We also plan to assess the potential of dynamic combinatorial chemistry for catalyst discovery and synthesis. We will synthesise a new set of metal-ion containing building blocks, and libraries made from mixtures of these and other building blocks will be screened for affinity for a transition state analogue for metal-ion catalysed hydrolysis, oxidation or Diels-Alder reactions.In collaboration with Prof. Sherrington and Dr. Cormack we will optimise the use of supported guests as tools for receptor synthesis and isolation. This approach should allow for the large-scale preparation of new receptors even where the guest-induced amplification is relatively inefficient.
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Organisation Website: http://www.cam.ac.uk