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Details of Grant 

EPSRC Reference: GR/S76564/01
Title: FARADAY: Development of Functional Assessment Tools to Evaluate the Pre-Clinical Performance of a Novel Knee Hemi-Arthroplasty Device
Principal Investigator: Taylor, Professor M
Other Investigators:
Barrett, Professor D
Researcher Co-Investigators:
Project Partners:
DePuy Synthes (International) Leeds General Infirmary
Department: Faculty of Engineering & the Environment
Organisation: University of Southampton
Scheme: Faraday (PreFEC)
Starts: 05 April 2004 Ends: 04 April 2006 Value (£): 97,959
EPSRC Research Topic Classifications:
Biomaterials
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
GR/S76557/01
Panel History:  
Summary on Grant Application Form
Evidence suggests that early intervention during the initial stages of osteoarthritis in young (less than 65 years) patients using more conservative devices may delay the need for total knee replacement. Advantages of early intervention include; minimal joint destruction; retention of functional cruciate ligaments and prevention of further disease progression. The primary aim of this project is to design and develop a number of composite design solutions for a novel surface hemi-arthroplasty device for either the medial or lateral compartment of the tibio-femoral joint. A composite structural design will be developed, the properties of which will be functionally graded to allow optimisation of the functional surface to minimise wear of the femoral cartilage and which will provide secure fixation to the tibia with minimal tissue resection. As part of the design and developmental process, two test methods will be developed and utilised to assess two key aspects of the performance of the novel device . (1) A virtual (finite element analysis) knee model to assess the interaction of the remaining anatomical structures . (2) An experimental model utilising large animal tissue based on knee joint and pendulum simulators to assess the impact of the prosthetic device on the wear and degeneration of the femoral articular cartilage.
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Organisation Website: http://www.soton.ac.uk